Researchers from the Swiss natural science and engineering university ETH Zurich have developed a self regulating biological gene network that they believe will make gout and kidney stones a thing of the past.
As humans evolved, we lost an enzyme that helps control levels of uric acid in the body. The enzyme, urate oxydase, is still present in most mammals, working to keep their uric acid in check. Uric acid is a chemical created when the body breaks down purines. Purines are natural substances found in all cells and almost all foods.
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Scientists Eradicate Gout in Mice
In the right quantity, uric acid is a powerful anti-oxidant and an important part of the detoxification process. But when blood levels get too high (over 6.8 mg/dl), the excess uric acid crystallizes into needle sharp crystals in the joints and tissues surrounding the joints, causing a painful form of arthritis known as gout. Excess uric acid can also be deposited in the kidneys as kidney stones.
Determined to reconstruct a system to keep uric acid in check in humans, the ETH researchers put together a biological network of genes they call UREX. The network has three components: a uric acid sensor that constantly monitors uric acid levels, a genetic circuit, and a component that releases urate oxydase into the blood.
The three components are programmed to perform certain functions both independently and in synch with each other, without any outside assistance. When the sensor detects high concentrations of uric acid, it automatically relays that information to the genetic circuit, which triggers the third component to release urate oxydase to lower uric acid levels to a healthy balance.
Amazingly, the gene network is contained in a single cell. Roughly two million of these cells are enclosed in a tiny implantable porous gelatin capsule for protection against an immune system attack. The implant can be removed at any time with no consequence.
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Scientists Eradicate Gout in Mice
ETH Zurich Professor Martin Fussenegger says the "molecular prosthesis" is a prime example of what can be achieved using synthetic biology. "Many medical problems are solved by introducing chemical substances (like gout medication) into the body from outside," he explains, "In our method, we repair a defective metabolic pathway and help the body to treat itself in the best possible way."
UREX has been successfully tested in mice, and the research team has filed a patent application for the gene network. Other partners are now responsible for bringing UREX to market. Fussenegger is confident that UREX will successfully complete the necessary testing in the near future, clearing the way for a finished product to hit the world market - a major development with potential to bring relief to millions of gout sufferers around the world who now rely on gout medication.
Alex Ray researches and writes about gout for the online resource www.colchicine.ca. She advises those using colchicine for gout that generic colchicine is still available in Canada, and recommends Big Mountain Drugs as a reliable Canadian pharmacy from which to buy colchicine online.
allabouthealth10: Gout could be a huge pain as well as a major inconvenience especially if left unattended correctly or right away. The good news is, there are tons of natural gout remedies you can do at your home.
Allopurinol was delivered being a significant new drug at some time through 1960s and ever since then, it's the most recognized and much prescribed strategy to gouty arthritis, a health condition that's characterized by the overburden of uric acid in your body. Allopurinol forbids the body's creation of uric acid; much like the way berries and also other veggies including celery do by minimizing...
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The cost of krystexxa
In between various newest technological innovations that can help you in dealing with gout is krystexxa. It's not a low priced healing and not a soul can assure you that it'll provide you with irreversible an end to gout. This kind of remedy necessitates you to visit the infusion center following every two weeks. You have to shell out 2 hours there within the center every...
A poll that had been conducted in the year 19th century says that the 73% from the first time gout intrusions were on the big toe - either on the left foot or the right foot or in many cases, even on both feet at the same time. The following most frequent attack was discovered for being at the ankle. However, even though the ankle gout was the 2nd most frequent onset, it accounted for almost 9...